Organic phosphoric acids and derivatives
Apexbio Technology LLC Fludarabine Phosphate (Fludara)(Synonyms: Fludara, Fludarabine phosphate, Fludarabine monophosphate, 2-Fluoro-ara-AMP), 10mg, CAS: 75607-67-9.
Fludarabine phosphate (CAS 75607-67-9) marketed as Fludara is a fluorinated nucleotide analog derived from vidarabine (ara-A) exhibiting antineoplastic activities by interfering with DNA synthesis Following rapid extracellular dephosphorylation to 2-fluoro-ara-A this metabolite is intracellularly phosphorylated by deoxycytidine kinase generating the active triphosphate metabolite 2-fluoro-ara-ATP The active metabolite inhibits critical enzymes including DNA polymerase alpha ribonucleotide reductase and DNA primase thereby disrupting DNA replication and ultimately impeding tumor cell proliferation This compound is broadly utilized in biomedical research focused on anticancer mechanisms and nucleotide metabolism studies
Apexbio Technology LLC Phosphatase Inhibitor Cocktail (2 Tubes, 100X) 100x(1ml A + 1ml B)
Protein phosphorylation regulates various cellular processes by controlling protein functions localization and interactions To study phosphorylation protection from endogenous phosphatases is needed as they reverse phosphorylation during sample preparation The Phosphatase Inhibitor Cocktail contains two formulations Tube A (in DMSO) targets serine/threonine phosphatases (PP1 PP2A) and alkaline phosphatases using inhibitors like Cantharidin Bromotetramisole and Microcystin LR Tube B (in aqueous solution) inhibits tyrosine acid and alkaline phosphatases using Sodium orthovanadate Sodium molybdate Sodium tartrate Imidazole and Sodium Fluoride This cocktail helps preserve phosphorylation during cell lysis and processing for biochemical assays such as immunoblotting immunoprecipitation kinase activity analysis and mass spectrometry
Chem-Impex International, Inc. Dibenzyl phosphate | 1623-08-1 | MFCD00004775 | 100G
Dibenzyl phosphate, 1623-08-1, MFCD00004775, 100G
Medchemexpress LLC Dope-peg-azide | 99.6% | 1000 (average) | 250 MG
DOPE-PEG-Azide (PEG MW 1000) is a phospholipid-PEG conjugate used as a biocompatible amphiphilic component in drug delivery and formulation research. It is supplied as a colorless to light yellow oil, characterized by high purity and stability under recommended storage conditions.
- Purity 99.62%.
- Average PEG molecular weight 1,000.
- Form: oil; colorless to light yellow.
- Useful for liposome and micelle formulation and azide-alkyne click bioconjugation.
- Available in laboratory packaging including 250 mg quantities.
- Storage recommendations: pure form -20°C; in solvent -80°C for 6 months or -20°C for 1 month.
- Intended for research use only.
Apexbio Technology LLC KN-93 Phosphate 1188890-41-6 10mM (in 1mL DMSO)
KN-93 Phosphate (CAS 1188890-41-6) is a small-molecule inhibitor targeting calcium/calmodulin-dependent protein kinase II (CaMKII) It is designed to selectively inhibit CaMKII thereby modulating cellular proliferation survival neurotransmitter regulation and related signal transduction pathways KN-93 Phosphate exerts its biological activity primarily by competitively binding to Ca2 /calmodulin disrupting their interaction with CaMKII and preventing CaMKII activation and autophosphorylation In cell-based studies KN-93 Phosphate demonstrates inhibitory activity with IC50 values of 9 M for CaMKII monomer and 3 M for CaMKII dodecamer Experimental models include hepatic stellate cells and NIH 3T3 fibroblasts Based on these pharmacological properties KN-93 Phosphate holds research potential in the study of cell cycle regulation apoptosis neurotransmitter synthesis and neurodegenerative disorders particularly Parkinson s disease models
Medchemexpress LLC Amdiglurax phosphate | 1270138-41-4 | 99.8% | C22H33N4O5P | 10MG
Amdiglurax phosphate (NSI-189 phosphate) is the phosphate salt of a neurogenic research compound used in preclinical studies to promote neurogenesis and provide neuroprotective effects. Supplied as a high-purity, white to off-white solid, it is intended for laboratory research use only.
- High purity (99.8%) suitable for research applications.
- White to off-white powder form for easy handling and dissolution.
- Validated storage recommendations for long-term stability.
- Documented neurogenic and neuroprotective activity in preclinical studies.
- Available in small quantities for experimental workflows.
Medchemexpress LLC Kn-93 phosphate | 1913269-12-1 | 99.7% | 599.03 g·mol⁻¹ | C26H32ClN2O8PS | 10 MG
KN-93 phosphate is the phosphate salt form of KN-93, a cell-permeable, reversible, competitive inhibitor of calmodulin-dependent kinase II (CaMKII) with a reported Ki of 370 nM. It is provided as a high-purity research reagent intended for in vitro and cell-based studies investigating CaMKII signaling pathways.
- High purity suitable for research applications.
- Water-soluble phosphate salt for improved solubility in aqueous assays.
- Reported Ki of 370 nM against CaMKII for potency reference.
- Available in small pack sizes to support screening and optimization.
- Provided with analytical data supporting quality and identity.
Medchemexpress LLC 9,11,15-trioxa-6-aza-10-phosphatritriacont-24-enoic acid, 10-hydroxy-5,16-dioxo-13-[(9Z)-1-oxo | 228706-30-7 | ≥98.0% | 858.13 g·mol⁻¹ | C46H84NO11P | 10 MG
DOPE-GA is a phospholipid reagent used in research to prepare liposomes for drug delivery and related applications. It is reported as a key raw material for preparing the liposome ELL-12 and may affect liposome structure, stability, and interactions with cells. Supplied for research use only.
eMolecules Key Organics/BIONET Pyridoxal 5 -phosphate hydrate 10mg 787745611 AS-19314 98 000 41468-25-1 MFCD00006333 247 143 C8H10NO6P
Key Organics/BIONET Pyridoxal 5 -phosphate hydrate 10mg 787745611 AS-19314 98 000 41468-25-1 MFCD00006333 247 143 C8H10NO6P
Apexbio Technology LLC KN-92 phosphate 1135280-28-2 10mg
KN-92 phosphate is a small-molecule analog of the Ca2 /calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 It is designed as an inactive control compound to distinguish CaMKII-specific effects in experimental settings KN-92 phosphate does not inhibit CaMKII activity and thus serves as a negative control for CaMKII inhibition studies Additionally KN-92 phosphate blocks certain voltage-gated potassium (Kv) channels such as Kv1 2 and Kv1 5 reducing steady-state current amplitudes upon depolarization Based on these pharmacological properties KN-92 phosphate holds research potential in investigating mechanisms underlying CaMKII-related signaling pathways and Kv channel functions